Jump to main content
Jump to site search

Issue 42, 2010
Previous Article Next Article

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

Author affiliations

Abstract

An efficient Michael–ketone aldol–dehydration domino reaction has been developed to afford spiro[cyclohex-2-enone-oxindole] motifs with high yields (up to 99%), excellent diastereoselectivities (dr >20 : 1) and enantioselectivities (up to 96% ee).

Graphical abstract: Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Aug 2010, accepted on 06 Sep 2010 and first published on 24 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC03032E
Citation: Chem. Commun., 2010,46, 8064-8066

  •   Request permissions

    Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

    L. Wang, L. Peng, J. Bai, Q. Huang, X. Xu and L. Wang, Chem. Commun., 2010, 46, 8064
    DOI: 10.1039/C0CC03032E

Search articles by author

Spotlight

Advertisements