Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 42, 2010
Previous Article Next Article

A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

Author affiliations

Abstract

A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The classical issue of lack of stereoselectivity in Ugi- and Passerini-type reactions is circumvented. The atom economic and convergent nature of the synthetic strategy require only very limited use of protective groups.

Graphical abstract: A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Jul 2010, accepted on 03 Sep 2010 and first published on 20 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02823A
Citation: Chem. Commun., 2010,46, 7918-7920

  •   Request permissions

    A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions

    A. Znabet, M. M. Polak, E. Janssen, F. J. J. de Kanter, N. J. Turner, R. V. A. Orru and E. Ruijter, Chem. Commun., 2010, 46, 7918
    DOI: 10.1039/C0CC02823A

Search articles by author

Spotlight

Advertisements