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Issue 39, 2010
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Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

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Abstract

The cationic porphyrin TPrPyP4, with four propyl substituents in the pyridinium rings, is evaluated in vitro by spectroscopic and polymerase-stop assays as a G4-DNA ligand and in cultured cells as a modulator of gene transcription. A comparison with the widely used TMPyP4 is presented.

Graphical abstract: Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

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Publication details

The article was received on 16 Jun 2010, accepted on 17 Aug 2010 and first published on 06 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC01912G
Chem. Commun., 2010,46, 7364-7366

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    Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): A comparative study with TMPyP4

    S. Cogoi and L. E. Xodo, Chem. Commun., 2010, 46, 7364
    DOI: 10.1039/C0CC01912G

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