Jump to main content
Jump to site search

Issue 29, 2010
Previous Article Next Article

Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

Author affiliations

Abstract

The mevalonate pathway is an important drug target for the treatment of cancer and cardiovascular disease. We synthesized and studied a new type of nitrogen-containing bisphosphonate analogs and developed a sensitive end point assay method for enzyme FPPS, which was used for inhibitor screening. One potent FPPS inhibitor was discovered, and the structure–activity relationship of bisphosphonates for the enzyme inactivation was studied.

Graphical abstract: Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Apr 2010, accepted on 20 May 2010 and first published on 14 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC00992J
Citation: Chem. Commun., 2010,46, 5340-5342
  •   Request permissions

    Discovery of potent inhibitor for farnesyl pyrophosphate synthase in the mevalonate pathway

    J. Gao, X. Chu, Y. Qiu, L. Wu, Y. Qiao, J. Wu and D. Li, Chem. Commun., 2010, 46, 5340
    DOI: 10.1039/C0CC00992J

Search articles by author

Spotlight

Advertisements