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Issue 37, 2010
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Solvent-free microwave-assisted multi-component reaction for preparation of 2-amino-1-aryl-2-(cyclohex-1-enyl)ethanones as precursors of pseudoephedrine analogues

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Abstract

Microwave irradiation of chloroacetylarenes and enamines induced an aza-Darzens reaction followed by rearrangement of the aziridinium intermediate to give (2-amino-3-alkenoyl)arenes that were reduced selectively to syn-β-aminoalcohols as pseudo-ephedrine analogues.

Graphical abstract: Solvent-free microwave-assisted multi-component reaction for preparation of 2-amino-1-aryl-2-(cyclohex-1-enyl)ethanones as precursors of pseudoephedrine analogues

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Publication details

The article was received on 10 Apr 2010, accepted on 28 Jul 2010 and first published on 25 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC00859A
Citation: Chem. Commun., 2010,46, 7037-7039

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    Solvent-free microwave-assisted multi-component reaction for preparation of 2-amino-1-aryl-2-(cyclohex-1-enyl)ethanones as precursors of pseudoephedrine analogues

    L. Ma and T. Inokuchi, Chem. Commun., 2010, 46, 7037
    DOI: 10.1039/C0CC00859A

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