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Issue 26, 2010
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A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

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Abstract

A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect® dendrimer but with lower cytotoxicity.

Graphical abstract: A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

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Article information


Submitted
17 Mar 2010
Accepted
14 May 2010
First published
01 Jun 2010

Chem. Commun., 2010,46, 4698-4700
Article type
Communication

A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

B. Newland, H. Tai, Y. Zheng, D. Velasco, A. Di Luca, S. M. Howdle, C. Alexander, W. Wang and A. Pandit, Chem. Commun., 2010, 46, 4698
DOI: 10.1039/C0CC00439A

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