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Issue 22, 2010
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Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

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Abstract

Use of a bis-dithiane deprotection–tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.

Graphical abstract: Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

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Publication details

The article was received on 22 Feb 2010, accepted on 12 Apr 2010 and first published on 05 May 2010


Article type: Communication
DOI: 10.1039/C0CC00056F
Chem. Commun., 2010,46, 3967-3969

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    Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

    J. L. Chen and M. A. Brimble, Chem. Commun., 2010, 46, 3967
    DOI: 10.1039/C0CC00056F

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