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Issue 24, 2010
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Modified siRNAs for the study of the PAZ domain

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Abstract

Chemical modifications aimed at stabilizing the interaction between the 3′-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

Graphical abstract: Modified siRNAs for the study of the PAZ domain

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Publication details

The article was received on 16 Feb 2010, accepted on 05 May 2010 and first published on 19 May 2010


Article type: Communication
DOI: 10.1039/C003221B
Chem. Commun., 2010,46, 4270-4272

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    Modified siRNAs for the study of the PAZ domain

    Á. Somoza, M. Terrazas and R. Eritja, Chem. Commun., 2010, 46, 4270
    DOI: 10.1039/C003221B

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