Issue 24, 2010
From the journal:

Chemical Communications

Modified siRNAs for the study of the PAZ domain†

Álvaro Somoza,*a   Montserrat Terrazasbc  and  Ramón Eritja*bc  

* Corresponding authors

a IMDEA-Nanociencia, 28049, Madrid, Spain
E-mail: alvaro.somoza@imdea.org
Fax: +34 914976855
Tel: +34 914973654

b Instituto de Química Avanzada de Cataluña, CSIC, C/Jordi Girona 18-26, Barcelona, Spain

c Institut de Recerca Biomèdica, CIBER-BBN, C/Baldiri Reixac 15, Barcelona, Spain
E-mail: ramon.eritja@irbbarcelona.org
Fax: +34 932045904
Tel: +34 934039942

Abstract

Chemical modifications aimed at stabilizing the interaction between the 3′-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

Graphical abstract: Modified siRNAs for the study of the PAZ domain

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Article information

DOI
https://doi.org/10.1039/C003221B
Article type
Communication
Submitted
16 Feb 2010
Accepted
05 May 2010
First published
19 May 2010

Chem. Commun., 2010,46, 4270-4272

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Modified siRNAs for the study of the PAZ domain

Á. Somoza, M. Terrazas and R. Eritja, Chem. Commun., 2010, 46, 4270 DOI: 10.1039/C003221B

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