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Issue 24, 2010
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Modified siRNAs for the study of the PAZ domain

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Abstract

Chemical modifications aimed at stabilizing the interaction between the 3′-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.

Graphical abstract: Modified siRNAs for the study of the PAZ domain

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Supplementary files

Article information


Submitted
16 Feb 2010
Accepted
05 May 2010
First published
19 May 2010

Chem. Commun., 2010,46, 4270-4272
Article type
Communication

Modified siRNAs for the study of the PAZ domain

Á. Somoza, M. Terrazas and R. Eritja, Chem. Commun., 2010, 46, 4270
DOI: 10.1039/C003221B

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