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Issue 15, 2010
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Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI

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Abstract

Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl2, Me3SiCH2MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.

Graphical abstract: Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI

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Publication details

The article was received on 11 Dec 2009, accepted on 19 Jan 2010 and first published on 09 Feb 2010


Article type: Communication
DOI: 10.1039/B926243A
Chem. Commun., 2010,46, 2674-2676

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    Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI

    M. Hatano, O. Ito, S. Suzuki and K. Ishihara, Chem. Commun., 2010, 46, 2674
    DOI: 10.1039/B926243A

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