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Issue 15, 2010
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Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI

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Abstract

Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl2, Me3SiCH2MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.

Graphical abstract: Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI

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Supplementary files

Article information


Submitted
11 Dec 2009
Accepted
19 Jan 2010
First published
09 Feb 2010

Chem. Commun., 2010,46, 2674-2676
Article type
Communication

Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI

M. Hatano, O. Ito, S. Suzuki and K. Ishihara, Chem. Commun., 2010, 46, 2674
DOI: 10.1039/B926243A

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