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Issue 12, 2010
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Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

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Abstract

An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.

Graphical abstract: Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

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Publication details

The article was received on 11 Dec 2009, accepted on 21 Jan 2010 and first published on 09 Feb 2010


Article type: Communication
DOI: 10.1039/B926174E
Citation: Chem. Commun., 2010,46, 2019-2021

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    Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction

    Q. Chen, T. Ganesh, Y. Jiang, A. Banerjee, S. Sharma, S. Bane, J. P. Snyder and D. G. I. Kingston, Chem. Commun., 2010, 46, 2019
    DOI: 10.1039/B926174E

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