Issue 9, 2010
From the journal:

Chemical Communications

Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers†

Cristian Samorì,a   Hanene Ali-Boucetta,b   Raquel Sainz,a   Chang Guo,b   Francesca Maria Toma,cd   Chiara Fabbro,c   Tatiana da Ros,c   Maurizio Prato,*c   Kostas Kostarelos*b  and  Alberto Bianco*a  

* Corresponding authors

a CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d’Immunologie et Chimie Thérapeutiques, 67000 Strasbourg, France
E-mail: A.Bianco@ibmc-cnrs.unistra.fr
Fax: +33 388 610680
Tel: +33 388 417088

b Nanomedicine Laboratory, Centre for Drug Delivery, The School of Pharmacy, University of London, 29–39 Brunswick Square, London, UK
E-mail: kostas.kostarelos@pharmacy.ac.uk
Fax: +44 20 7757 5942
Tel: +44 20 77535861

c Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy
E-mail: prato@units.it
Fax: +39 040 52577
Tel: +39 040 5587883

d SISSA, 34014 Trieste, Italy

Abstract

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

Graphical abstract: Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers

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Article information

DOI
https://doi.org/10.1039/B923560D
Article type
Communication
Submitted
11 Nov 2009
Accepted
10 Dec 2009
First published
23 Dec 2009

Chem. Commun., 2010,46, 1494-1496

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Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers

C. Samorì, H. Ali-Boucetta, R. Sainz, C. Guo, F. M. Toma, C. Fabbro, T. da Ros, M. Prato, K. Kostarelos and A. Bianco, Chem. Commun., 2010, 46, 1494 DOI: 10.1039/B923560D

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