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Issue 18, 2010
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First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

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Abstract

77Se NMR offers superior sensing of chirality within the structure of the diastereomers (Δδ up to 6.1 ppm), compared to 13Cδ < 1 ppm) and 1H (Δδ < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.

Graphical abstract: First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

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Publication details

The article was received on 09 Nov 2009, accepted on 22 Feb 2010 and first published on 19 Mar 2010


Article type: Communication
DOI: 10.1039/B923359H
Citation: Chem. Commun., 2010,46, 3212-3214
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    First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

    N. V. Orlov and V. P. Ananikov, Chem. Commun., 2010, 46, 3212
    DOI: 10.1039/B923359H

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