Issue 42, 2010
From the journal:

Chemical Communications

Efficient photoactivation of a Diels-Alderase ribozyme†

Alexander Nierth,a   Marco Singera  and  Andres Jäschke*a  

* Corresponding authors

a Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany
E-mail: jaeschke@uni-hd.de
Fax: +49 (0)6221-54-6430
Tel: +49 (0)6221-54-4851

Abstract

Here we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of a single hydrogen bond.

Graphical abstract: Efficient photoactivation of a Diels-Alderase ribozyme

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Article information

DOI
https://doi.org/10.1039/C0CC03162C
Article type
Communication
Submitted
10 Aug 2010
Accepted
09 Sep 2010
First published
27 Sep 2010

Chem. Commun., 2010,46, 7975-7977

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Efficient photoactivation of a Diels-Alderase ribozyme

A. Nierth, M. Singer and A. Jäschke, Chem. Commun., 2010, 46, 7975 DOI: 10.1039/C0CC03162C

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