Issue 44, 2010
From the journal:

Chemical Communications

Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing†

Irina V. Astakhova,a   Dorthe Lindegaard,a   Vladimir A. Korshunb  and  Jesper Wengel*a  

* Corresponding authors

a Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
E-mail: jwe@ifk.sdu.dk
Fax: +45 6615 8780
Tel: +45 6550 2510

b Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia
E-mail: korshun@ibch.ru
Fax: +7 495 429 8710
Tel: +7 495 429 8710

Abstract

Functionalisation of 2′-amino-LNA oligonucleotides with 1-, 2- and 4-(phenylethynyl)pyrene fluorophores via a carbonyl linker (PEPyc) resulted in efficient interstrand communication systems in nucleic acid duplexes, providing effective tools for stabilization of nanostructures and fluorescence monitoring of DNA self-assembly.

Graphical abstract: Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

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Article information

DOI
https://doi.org/10.1039/C0CC03026K
Article type
Communication
Submitted
04 Aug 2010
Accepted
10 Sep 2010
First published
04 Oct 2010

Chem. Commun., 2010,46, 8362-8364

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Novel interstrand communication systems within DNA duplexes based on 1-, 2- and 4-(phenylethynyl)pyrenes attached to 2′-amino-LNA: high-affinity hybridization and fluorescence sensing

I. V. Astakhova, D. Lindegaard, V. A. Korshun and J. Wengel, Chem. Commun., 2010, 46, 8362 DOI: 10.1039/C0CC03026K

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