Issue 46, 2010

Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

Abstract

The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors.

Graphical abstract: Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

Supplementary files

Article information

Article type
Communication
Submitted
29 Jul 2010
Accepted
27 Sep 2010
First published
22 Oct 2010

Chem. Commun., 2010,46, 8857-8859

Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

S. C. Stolze, M. Meltzer, M. Ehrmann and M. Kaiser, Chem. Commun., 2010, 46, 8857 DOI: 10.1039/C0CC02889D

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