Issue 39, 2010

Direct observation of key intermediates by negative-ion electrospray ionisation mass spectrometry in palladium-catalysed cross-coupling

Abstract

Negative-ion electrospray ionisation mass spectrometry with an anionic phosphine ligand enables detection of key intermediates in the Sonogashira reaction. MS/MS techniques are used to generate a Hammett plot for the key reductive elimination step.

Graphical abstract: Direct observation of key intermediates by negative-ion electrospray ionisation mass spectrometry in palladium-catalysed cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2010
Accepted
19 Aug 2010
First published
07 Sep 2010

Chem. Commun., 2010,46, 7412-7414

Direct observation of key intermediates by negative-ion electrospray ionisation mass spectrometry in palladium-catalysed cross-coupling

K. L. Vikse, M. A. Henderson, A. G. Oliver and J. S. McIndoe, Chem. Commun., 2010, 46, 7412 DOI: 10.1039/C0CC02773A

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