Issue 38, 2010
From the journal:

Chemical Communications

Direct observation and pH control of reversed supramolecular chirality in insulinfibrils by vibrational circular dichroism†

Dmitry Kurouski,b   Rosina A. Lombardi,a   Rina K. Dukor,c   Igor K. Lednev*b  and  Laurence A. Nafie*ac  

* Corresponding authors

a Department of Chemistry, Syracuse University, Syracuse, New York, USA
E-mail: lnafie@syr.edu

b Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, USA
E-mail: lednev@albany.edu

c BioTools, Inc., 17546 Bee Line Hwy, Jupiter, Florida, USA
E-mail: rkdukor@aol.com

Abstract

The controlled reversal of supramolecular helical chirality in protein fibrils is reported for the first time. Normal or reversed insulin fibrils were grown by precise adjustment of pH. AFM images show two polymorphs corresponding to opposite senses of helical twist of the supramolecular structure with the same cross-β-sheet core.

Graphical abstract: Direct observation and pH control of reversed supramolecular chirality in insulin fibrils by vibrational circular dichroism

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Article information

DOI
https://doi.org/10.1039/C0CC02423F
Article type
Communication
Submitted
08 Jul 2010
Accepted
07 Aug 2010
First published
01 Sep 2010

Chem. Commun., 2010,46, 7154-7156

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Direct observation and pH control of reversed supramolecular chirality in insulin fibrils by vibrational circular dichroism

D. Kurouski, R. A. Lombardi, R. K. Dukor, I. K. Lednev and L. A. Nafie, Chem. Commun., 2010, 46, 7154 DOI: 10.1039/C0CC02423F

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