Issue 38, 2010
From the journal:

Chemical Communications

Chiral cobalt-catalyzed enantioselective aerobic oxidation of α-hydroxy esters†‡

Santosh Kumar Alamsettia  and  Govindasamy Sekar*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai, India
E-mail: gsekar@iitm.ac.in
Fax: +91 44 2257 4202
Tel: +91 44 2257 4229

Abstract

A chiral cobalt-catalyzed enantioselective aerobic oxidative kinetic resolution of (±)-α-hydroxy esters, using molecular oxygen as a sole oxidant, is reported and a maximum of selectivity factor (s) 31.9 was achieved with >99% enantiomeric excess for unreacted α-hydroxy esters.

Graphical abstract: Chiral cobalt-catalyzed enantioselective aerobic oxidation of α-hydroxy esters

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Article information

DOI
https://doi.org/10.1039/C0CC01917H
Article type
Communication
Submitted
16 Jun 2010
Accepted
04 Aug 2010
First published
27 Aug 2010

Chem. Commun., 2010,46, 7235-7237

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Chiral cobalt-catalyzed enantioselective aerobic oxidation of α-hydroxy esters

S. K. Alamsetti and G. Sekar, Chem. Commun., 2010, 46, 7235 DOI: 10.1039/C0CC01917H

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