Issue 36, 2010
From the journal:

Chemical Communications

A novel degradable polymeric carrier for selective release and imaging of magnetic nanoparticles†

Dongyun Chen,a   Najun Li,a   Hongwei Gu,a   Xuewei Xia,a   Qingfeng Xu,a   Jianfeng Ge,a   Jianmei Lu*a  and  Yonggang Li*b  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, Key Laboratory of Absorbent Materials and Techniques for Environment, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
E-mail: lujm@suda.edu.cn
Fax: +86-(0)512-6588 0367
Tel: +86-(0)512-6588 0367

b Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
E-mail: liyonggang224@163.com

Abstract

A water-soluble, pH-responsive copolymer was synthesized successfully and used as a polymeric carrier to deliver hydrophobic paramagnetic nanoparticles into cells. In an acidic environment, the nanoparticles aggregate as the copolymer degrades, resulting in the enhancement of an in vitro MRI signal.

Graphical abstract: A novel degradable polymeric carrier for selective release and imaging of magnetic nanoparticles

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Article information

DOI
https://doi.org/10.1039/C0CC01857K
Article type
Communication
Submitted
12 Jun 2010
Accepted
30 Jul 2010
First published
16 Aug 2010

Chem. Commun., 2010,46, 6708-6710

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A novel degradable polymeric carrier for selective release and imaging of magnetic nanoparticles

D. Chen, N. Li, H. Gu, X. Xia, Q. Xu, J. Ge, J. Lu and Y. Li, Chem. Commun., 2010, 46, 6708 DOI: 10.1039/C0CC01857K

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