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Issue 38, 2010
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Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran

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Abstract

A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.

Graphical abstract: Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran

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Publication details

The article was received on 01 Jun 2010, accepted on 05 Aug 2010 and first published on 27 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC01682A
Citation: Chem. Commun., 2010,46, 7130-7132

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    Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran

    M. Hammarson, J. Andersson, S. Li, P. Lincoln and J. Andréasson, Chem. Commun., 2010, 46, 7130
    DOI: 10.1039/C0CC01682A

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