Issue 38, 2010
From the journal:

Chemical Communications

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe†

Lei Cui,a   Ye Zhong,a   Weiping Zhu,a   Yufang Xu*a  and  Xuhong Qian*a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China
E-mail: yfxu@ecust.edu.cn, xhqian@ecust.edu.cn
Fax: +86-21-64252603
Tel: +86-21-64251399

Abstract

A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

Graphical abstract: Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0CC01000F
Article type
Communication
Submitted
18 Apr 2010
Accepted
19 Jul 2010
First published
26 Aug 2010

Chem. Commun., 2010,46, 7121-7123

Permissions

Request permissions

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

L. Cui, Y. Zhong, W. Zhu, Y. Xu and X. Qian, Chem. Commun., 2010, 46, 7121 DOI: 10.1039/C0CC01000F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements