Issue 31, 2010
From the journal:

Chemical Communications

“Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions†

Amit Kumar,a   Uriel J. Erasquin,a   Guoting Qin,ab   King Lib  and  Chengzhi Cai*a  

* Corresponding authors

a Department of Chemistry, University of Houston, Houston, USA
E-mail: cai@uh.edu
Fax: +1 713 743 2709
Tel: +1 713 743 2710

b Department of Radiology, The Methodist Hospital Research Institute, Houston, USA

Abstract

A versatile and stable liposomal platform is developed for rapid optimization of its peripheral composition. The platform is based on polydiacetylene lipids terminated with alkynyl groups. Conditions for copper-catalyzed azide–alkyne cycloaddition (a “click” reaction) are optimized for rapid attachment of azides with controlled composition onto the liposomes.

Graphical abstract: “Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions

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Article information

DOI
https://doi.org/10.1039/C0CC00784F
Article type
Communication
Submitted
06 Apr 2010
Accepted
01 Jun 2010
First published
28 Jun 2010

Chem. Commun., 2010,46, 5746-5748

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“Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions

A. Kumar, U. J. Erasquin, G. Qin, K. Li and C. Cai, Chem. Commun., 2010, 46, 5746 DOI: 10.1039/C0CC00784F

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