Issue 25, 2010
From the journal:

Chemical Communications

Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt†

Feng Yu,a   Xiaomin Sun,a   Zhichao Jin,a   Shigang Wen,a   Xinmiao Liang*a  and  Jinxing Ye*a  

* Corresponding authors

a Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: yejx@ecust.edu.cn, liangxm@ecust.edu.cn

Abstract

An unprecedented enantioselective Michael addition of various ketones to maleimides catalyzed by a simple bifunctional primary amine, monosulfonyl DPEN salt, is reported and provides the desired adducts in good to excellent yields (up to 99%) with excellent enantioselectivities (up to 99%).

Graphical abstract: Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt

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Article information

DOI
https://doi.org/10.1039/C0CC00774A
Article type
Communication
Submitted
05 Apr 2010
Accepted
22 Apr 2010
First published
18 May 2010

Chem. Commun., 2010,46, 4589-4591

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Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt

F. Yu, X. Sun, Z. Jin, S. Wen, X. Liang and J. Ye, Chem. Commun., 2010, 46, 4589 DOI: 10.1039/C0CC00774A

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