Issue 30, 2010

Construction of a quaternary carbon at the carbonylcarbon of the cyclohexane ring

Abstract

High SN2′ selectivity in the allylic substitution of cyclohexylidene ethyl picolinates with copper reagents prepared from RMgBr and CuBr·Me2S was realized by addition of ZnX2 (X = I, Br, Cl). Furthermore, ZnX2 accelerated the reaction with the bulky iPr reagent.

Graphical abstract: Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring

Supplementary files

Article information

Article type
Communication
Submitted
29 Mar 2010
Accepted
09 Jun 2010
First published
29 Jun 2010

Chem. Commun., 2010,46, 5482-5484

Construction of a quaternary carbon at the carbonyl carbon of the cyclohexane ring

Y. Kaneko, Y. Kiyotsuka, H. P. Acharya and Y. Kobayashi, Chem. Commun., 2010, 46, 5482 DOI: 10.1039/C0CC00653J

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