Issue 22, 2010
From the journal:

Chemical Communications

Remarkable effect of phosphine on the reactivity of O,P-acetal—efficient substitution reaction of O,P-acetal†

Hiromichi Fujioka,*a   Akihiro Goto,a   Kazuki Otake,a   Ozora Kubo,a   Kenzo Yahata,a   Yoshinari Sawama‡a  and  Tomohiro Maegawaa  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan
E-mail: fujioka@phs.osaka-u.ac.jp
Fax: +8166798229
Tel: +8166798225

Abstract

The structure and electronic nature of the phosphine have a significant influence on not only the formation, but also the subsequent transformation of O,P-acetals. The O,P-acetals generated from tris(o-tolyl)phosphine [(o-tol)3P] underwent efficient substitution reactions with various nucleophiles.

Graphical abstract: Remarkable effect of phosphine on the reactivity of O,P-acetal—efficient substitution reaction of O,P-acetal

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Article information

DOI
https://doi.org/10.1039/C0CC00170H
Article type
Communication
Submitted
01 Mar 2010
Accepted
07 Apr 2010
First published
07 May 2010

Chem. Commun., 2010,46, 3976-3978

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Remarkable effect of phosphine on the reactivity of O,P-acetal—efficient substitution reaction of O,P-acetal

H. Fujioka, A. Goto, K. Otake, O. Kubo, K. Yahata, Y. Sawama and T. Maegawa, Chem. Commun., 2010, 46, 3976 DOI: 10.1039/C0CC00170H

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