Issue 28, 2010
From the journal:

Chemical Communications

Photochemically driven intercalation of small molecules into DNA by in situ irradiation†

Maria Letizia Di Pietro,a   Fausto Puntoriero,a   Fabien Tuyéras,b   Philippe Ochsenbein,c   Philippe P. Lainé*b  and  Sebastiano Campagna*a  

* Corresponding authors

a Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Via Sperone 31, 98166 Messina, Italy
E-mail: campagna@unime.it

b Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Université Paris Descartes, 45 rue des Saints Pères, Paris Cedex 06, France
E-mail: philippe.laine@parisdescartes.fr

c Sanofi-Aventis Recherche, 371 rue du Professeur Blayac, 34184 Montpellier Cedex 04, France

Abstract

Intercalation of small molecules into DNA is photochemically achieved by in situ irradiation of a tetraaryl-pyridinium species. Such a “DNA intercalation on demand” process could highlight an alternative pathway to anticancer basic research, based on photo-activable DNA binders.

Graphical abstract: Photochemically driven intercalation of small molecules into DNA by in situ irradiation

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Article information

DOI
https://doi.org/10.1039/C002748K
Article type
Communication
Submitted
09 Feb 2010
Accepted
18 May 2010
First published
11 Jun 2010

Chem. Commun., 2010,46, 5169-5171

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Photochemically driven intercalation of small molecules into DNA by in situ irradiation

M. L. Di Pietro, F. Puntoriero, F. Tuyéras, P. Ochsenbein, P. P. Lainé and S. Campagna, Chem. Commun., 2010, 46, 5169 DOI: 10.1039/C002748K

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