Issue 20, 2010
From the journal:

Chemical Communications

Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymerassembly for targeted drug delivery†

Yu-Cai Wang,a   Juan Wu,a   Yang Li,b   Jin-Zhi Du,a   You-Yong Yuanb  and  Jun Wang*b  

* Corresponding authors

a Department of Polymer Science and Engineering and CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China

b Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People's Republic of China
E-mail: jwang699@ustc.edu.cn
Tel: (+86) 551 3600335

Abstract

We report the preparation of biodegradable nanoscopic hydrogels and their application for targeted drug delivery. The nanogel is synthesized in a template-free method by photo-crosslinking salt-induced polymer assemblies. With convenient incorporation of targeted lactosyl moieties, the nanogels efficiently deliver doxorubicin to HepG2 cells through receptor-mediated internalization.

Graphical abstract: Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/C002620D
Article type
Communication
Submitted
08 Feb 2010
Accepted
16 Mar 2010
First published
08 Apr 2010

Chem. Commun., 2010,46, 3520-3522

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Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery

Y. Wang, J. Wu, Y. Li, J. Du, Y. Yuan and J. Wang, Chem. Commun., 2010, 46, 3520 DOI: 10.1039/C002620D

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