Issue 19, 2010
From the journal:

Chemical Communications

Efficient, mild and completely regioselective synthesis of substituted pyridines†

Hans Andersson,a   Thomas Sainte-Luce Banchelin,a   Sajal Das,a   Roger Olsson*bc  and  Fredrik Almqvist*a  

* Corresponding authors

a Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden
E-mail: Fredrik-almqvist@chem.umu.se
Fax: +46-90-786 7655
Tel: +46-90-786 6925

b ACADIA Pharmaceuticals AB, Medeon Science Park S-20512, Malmö, Sweden
E-mail: roger@acadia-pharm.com

c Department of Chemistry, University of Gothenburg, SE-41296 Gothenburg, Sweden
E-mail: oroger@chem.gu.se
Fax: +46 31 772 38 40
Tel: +46 736 25 34 87

Abstract

Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (−78 to −20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

Graphical abstract: Efficient, mild and completely regioselective synthesis of substituted pyridines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C000748J
Article type
Communication
Submitted
12 Jan 2010
Accepted
16 Feb 2010
First published
16 Mar 2010

Chem. Commun., 2010,46, 3384-3386

Permissions

Request permissions

Efficient, mild and completely regioselective synthesis of substituted pyridines

H. Andersson, T. Sainte-Luce Banchelin, S. Das, R. Olsson and F. Almqvist, Chem. Commun., 2010, 46, 3384 DOI: 10.1039/C000748J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements