Issue 10, 2010
From the journal:

Chemical Communications

A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation†

C. E. Stanley,‡ab   K. S. Elvira,‡ac   X. Z. Niu,ac   A. D. Gee,d   O. Ces,*ab   J. B. Edel*ac  and  A. J. deMello*a  

* Corresponding authors

a Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, UK
E-mail: o.ces@imperial.ac.uk, joshua.edel@imperial.ac.uk, a.demello@imperial.ac.uk

b Chemical Biology Centre, Imperial College London, Exhibition Road, South Kensington, London, UK

c Institute of Biomedical Engineering, Imperial College London, Exhibition Road, South Kensington, London, UK

d GSK, Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK

Abstract

We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

Graphical abstract: A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation

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Article information

DOI
https://doi.org/10.1039/B924897H
Article type
Communication
Submitted
26 Nov 2009
Accepted
05 Jan 2010
First published
25 Jan 2010

Chem. Commun., 2010,46, 1620-1622

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A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation

C. E. Stanley, K. S. Elvira, X. Z. Niu, A. D. Gee, O. Ces, J. B. Edel and A. J. deMello, Chem. Commun., 2010, 46, 1620 DOI: 10.1039/B924897H

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