Issue 4, 2010

Chemical rescue of protein tyrosine phosphatase activity

Abstract

We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.

Graphical abstract: Chemical rescue of protein tyrosine phosphatase activity

Supplementary files

Article information

Article type
Communication
Submitted
23 Sep 2009
Accepted
04 Nov 2009
First published
18 Nov 2009

Chem. Commun., 2010,46, 637-639

Chemical rescue of protein tyrosine phosphatase activity

V. L. Chen and A. C. Bishop, Chem. Commun., 2010, 46, 637 DOI: 10.1039/B919815F

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