Issue 8, 2010
From the journal:

Chemical Communications

Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes viaPd/Cu-catalyzed phosphonium coupling†‡

Fu-An Kang,*a   James C . Lanter,a   Chaozhong Cai,a   Zhihua Suia  and  William V. Murraya  

* Corresponding authors

a Johnson & Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, USA
E-mail: fkang@its.jnj.com
Fax: +1 215 540 4627
Tel: +1 215 628 7895

Abstract

The first chemoselective direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes has been achieved via C–H/C–OH bond activations with direct C(sp2)–C(sp) bond formation, which is in line with ideal synthesis using readily available materials.

Graphical abstract: Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling

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Article information

DOI
https://doi.org/10.1039/B917777A
Article type
Communication
Submitted
28 Aug 2009
Accepted
11 Dec 2009
First published
11 Jan 2010

Chem. Commun., 2010,46, 1347-1349

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Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling

F. Kang, J. C. . Lanter, C. Cai, Z. Sui and W. V. Murray, Chem. Commun., 2010, 46, 1347 DOI: 10.1039/B917777A

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