Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics

Yali Li; Khadijah Hindi; Kristin M. Watts; Jane B. Taylor; Ke Zhang; Zicheng Li; David A. Hunstad; Carolyn L. Cannon; Wiley J. Youngs; Karen L. Wooley

doi:10.1039/B916559B

Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics†

Yali Li,^a Khadijah Hindi,^b Kristin M. Watts,^b Jane B. Taylor,^b Ke Zhang,^a Zicheng Li,^a David A. Hunstad,*^bc Carolyn L. Cannon,*^bc Wiley J. Youngs*^d and Karen L. Wooley*^ae

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* Corresponding authors

^a Departments of Chemistry and Radiology, Washington University, St. Louis, USA

^b Department of Pediatrics, Washington University School of Medicine, St. Louis, USA
E-mail: cannon_c@kids.wustl.edu
Fax: +1 314 286-2895
Tel: +1 314 286-2954

^c Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, USA
E-mail: hunstad_d@kids.wustl.edu
Fax: +1 314 286-2895
Tel: +1 314 286-2874

^d Department of Chemistry and Center for Silver Therapeutics Research, University of Akron, Akron, USA
E-mail: youngs@uakron.edu
Fax: +1 330 972-7370
Tel: +1 330 972-5362

^e Department of Chemistry and Department of Chemical Engineering, Texas A&M University, College Station, USA
E-mail: wooley@mail.chem.tamu.edu
Fax: +1 979 862-1137
Tel: +1 979 845-4077

Abstract

Amphiphilic polymer nanoparticles loaded with silver cations or/and N-heterocyclic carbene–silver complexes were assessed as antimicrobial agents against Gram-negative pathogens Escherichia coli and Pseudomonas aeruginosa.

Chemical Communications

Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics†

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Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics

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