Issue 5, 2010
From the journal:

Chemical Communications

Calicheamicin γ1I and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study†

Toyonobu Usuki,*a   Mari Kawai,a   Koji Nakanishib  and  George A. Ellestad*b  

* Corresponding authors

a Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan
E-mail: t-usuki@sophia.ac.jp
Fax: 813 32383361
Tel: 813 32383446

b Department of Chemistry, Columbia University, 3000 Broadway, New York, USA
E-mail: gae2104@columbia.edu
Fax: 1212 932 1289
Tel: 1212 854 5356

Abstract

ESR study of enediyne calicheamicin γ1I with phenyl tert-butyl nitrone (PBN) gave a significant kinetic isotope effect (kH/kD = 1.8) for the formation of the phenyl radical PBN monoadducts.

Graphical abstract: Calicheamicin γ1I and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study

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Article information

DOI
https://doi.org/10.1039/B913414J
Article type
Communication
Submitted
06 Jul 2009
Accepted
10 Nov 2009
First published
25 Nov 2009

Chem. Commun., 2010,46, 737-739

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Calicheamicin γ1I and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study

T. Usuki, M. Kawai, K. Nakanishi and G. A. Ellestad, Chem. Commun., 2010, 46, 737 DOI: 10.1039/B913414J

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