Jump to main content
Jump to site search

Issue 2, 2010
Previous Article Next Article

Recent advances in on-line multidimensional liquid chromatography

Author affiliations

Abstract

Multidimensional liquid chromatography (MD LC) has, due to enhanced peak capacity compared to one-dimensional LC, become an important analytical tool for separating components in complex samples, e.g. in proteomics. MD LC can be performed both on-line and off-line. Because of the advantages like possible automation and minimal sample loss, on-line MD LC has appeared to be very attractive also for high throughput analysis. This review includes only on-line coupled MD LC. Different aspects related to the compatibility of separation principles and column dimensions are highlighted and recent applications using on-line mainly two-dimensional (2D) LC have been included.

Graphical abstract: Recent advances in on-line multidimensional liquid chromatography

Back to tab navigation

Publication details

The article was received on 02 Oct 2009, accepted on 02 Dec 2009 and first published on 23 Dec 2009


Article type: Review Article
DOI: 10.1039/B9AY00194H
Citation: Anal. Methods, 2010,2, 110-122
  •   Request permissions

    Recent advances in on-line multidimensional liquid chromatography

    H. Malerod, E. Lundanes and T. Greibrokk, Anal. Methods, 2010, 2, 110
    DOI: 10.1039/B9AY00194H

Search articles by author

Spotlight

Advertisements