First detection of free d-amino acids in human nails by combination of derivatization and UPLC-ESI-TOF-MS

Abstract

The resolution of free DL-amino acids in the human nail was carried out by combination of the R(−)-DBD-PyNCS derivatives and UPLC-ESI-TOF-MS. As we know, for the first time, these five kinds of D-amino acids, were determined from human nail samples. Fifteen kinds of L-amino acids were also recognized from human nails. Application to DL-amino acids in healthy person and diabetes patients nails is also described in this communication.