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Issue 9, 2010
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A flow-injection chemiluminescence method for determination of cinchona alkaloids in pharmaceuticals and biological fluids

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Abstract

A new analytical method for the determination of cinchona alkaloids by flow-injection sampling and chemiluminescence (CL) detection is developed. A weak CL can be emitted by oxidation reaction of cinchona alkaloid with potassium permanganate. The conditions for CL emission were investigated and optimized. The linear range of 1.0 × 10−7 – 8.0 × 10−5 g mL−1 was obtained for quinine, quinidine and cinchonine. The detection limit was 3.2 × 10−8 g mL−1 for quinine and 3.0 × 10−8 g mL−1 for quinidine and cinchonine. The recoveries of the three drugs from urine and serum samples were in the range of 95.0–105% with RSDs of 1.7–2.0%. The proposed method was used for the determination of cinchona alkaloids in pharmaceuticals and biological fluids with satisfactory result. The possible CL mechanism is also discussed.

Graphical abstract: A flow-injection chemiluminescence method for determination of cinchona alkaloids in pharmaceuticals and biological fluids

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Publication details

The article was received on 24 Mar 2010, accepted on 05 Jun 2010 and first published on 08 Jul 2010


Article type: Paper
DOI: 10.1039/C0AY00184H
Anal. Methods, 2010,2, 1270-1274

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    A flow-injection chemiluminescence method for determination of cinchona alkaloids in pharmaceuticals and biological fluids

    L. Li and H. Sun, Anal. Methods, 2010, 2, 1270
    DOI: 10.1039/C0AY00184H

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