Analytical methods and strategies in the study of plant polyphenolics in clinical samples

Abstract

Plant phenolics are secondary metabolites that exhibit a number of physiological effects in living organisms, including humans. These compounds form an integral part of the human diet and many of them are important components of phyto-preparations. Developments in the analytical methods for certain polyphenolic compounds and their analysis in clinical samples (plasma, urine, tissues, and organs) are described. The main aim of this review is to present the application of modern methods, especially chromatographic approaches, mass spectrometry, NMR, electrochemistry, and radioactivity labelling-based methods in the research of plant polyphenolics and the study of their biological activities.