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Issue 11, 2010
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DNA hybridization induced selective encapsulation of small dye molecules in dendrimer based microcapsules

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Abstract

A novel approach for selectively encapsulating Cy5 dye molecules via DNA hybridization in cationic phosphorus dendrimers (G4+)/polystyrenesulfonate (PSS) microcapsules has been developed. The hybridization between Cy5 labeled single strand DNA (ssDNA) targets and complementary ssDNA probes was performed in the microcapsules. During hybridization, the ssDNA targets acted as ‘vehicles’ and Cy5 dye molecules as ‘cargos’, which led to the selective encapsulation of the Cy5 molecules inside the capsules. The approach may be applied for many small molecules, which are usually difficult to be encapsulated due to their diffusion properties in microcapsules.

Graphical abstract: DNA hybridization induced selective encapsulation of small dye molecules in dendrimer based microcapsules

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Publication details

The article was received on 20 May 2010, accepted on 04 Aug 2010 and first published on 15 Sep 2010


Article type: Paper
DOI: 10.1039/C0AN00334D
Citation: Analyst, 2010,135, 2939-2944

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    DNA hybridization induced selective encapsulation of small dye molecules in dendrimer based microcapsules

    C. Feng, A. Caminade, J. Majoral, J. Gu, S. Zhu, H. Su, X. Hu and D. Zhang, Analyst, 2010, 135, 2939
    DOI: 10.1039/C0AN00334D

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