Issue 8, 2010

Recent advances in electrochemical DNA hybridization sensors

Abstract

Even with the advent of industry produced electrochemical DNA analysis chips, electrochemical DNA hybridization detection continues to be an intensive research focus area. The advantages of electrochemical detection continue to inspire efforts to improve selectivity and sensitivity. Here, we summarize the landscape of recent efforts in electrochemical DNA hybridization detection. We specifically focus on some main areas from where novel work continues to originate: redox active molecules designed for specific interaction with double stranded DNA, DNA mimics to eliminate background electrochemical signals, external nanoparticle or enzyme modifications for sensitivity enhancements, split and self-hybridizing single stranded DNA probe modifications, and novel catalytic oxidation techniques. Additionally, we touch on the use of DNA hybridization sensors to monitor alternative biochemical (non-DNA hybridization) processes.

Graphical abstract: Recent advances in electrochemical DNA hybridization sensors

Article information

Article type
Minireview
Submitted
25 Feb 2010
Accepted
18 Apr 2010
First published
25 May 2010

Analyst, 2010,135, 1817-1829

Recent advances in electrochemical DNA hybridization sensors

E. G. Hvastkovs and D. A. Buttry, Analyst, 2010, 135, 1817 DOI: 10.1039/C0AN00113A

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