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Issue 7, 2009
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Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

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Abstract

Using sacrificial sugar structures, we have formed a 3D fluidic vascular network in a polymeric matrix. Melt-spun sugar fibers (cotton candy) were used to form channels with diameters and densities similar to those of capillaries. To interface to macroscopic fluidic systems, larger sacrificial sugar structures were used to form an artificial inlet and outlet. To verify that the channel network supported flow, we used video fluorescence microscopy to image both 2 µm fluorescent polystyrene spheres in an aqueous solution and fluorescently labeled blood. This fabrication process may be applied to a wide range of polymeric materials and is rapid, inexpensive, and highly scalable.

Graphical abstract: Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

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Supplementary files

Article information


Submitted
07 Nov 2008
Accepted
23 Jan 2009
First published
09 Feb 2009

Soft Matter, 2009,5, 1354-1357
Article type
Communication

Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

L. M. Bellan, S. P. Singh, P. W. Henderson, T. J. Porri, H. G. Craighead and J. A. Spector, Soft Matter, 2009, 5, 1354
DOI: 10.1039/B819905A

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