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Issue 3, 2009
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pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

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Abstract

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

Graphical abstract: pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

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Submitted
12 Sep 2008
Accepted
11 Nov 2008
First published
28 Nov 2008

Soft Matter, 2009,5, 529-532
Article type
Communication

pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

A. Kishimura, S. Liamsuwan, H. Matsuda, W. Dong, K. Osada, Y. Yamasaki and K. Kataoka, Soft Matter, 2009, 5, 529
DOI: 10.1039/B815884C

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