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Issue 12, 2009
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The effect of microwave irradiation on DNA hybridization

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Abstract

The effect of microwave irradiation on DNA/DNA hybridization has been studied under controlled power and temperature conditions. It was discovered that microwave irradiation led to the melting of double-stranded deoxyoligonucleotides well below their thermal melting temperature and independent of the length of the deoxyoligonucleotides. These observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating.

Graphical abstract: The effect of microwave irradiation on DNA hybridization

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Article information


Submitted
20 Feb 2009
Accepted
17 Apr 2009
First published
01 May 2009

Org. Biomol. Chem., 2009,7, 2506-2508
Article type
Communication

The effect of microwave irradiation on DNA hybridization

W. F. Edwards, D. D. Young and A. Deiters, Org. Biomol. Chem., 2009, 7, 2506
DOI: 10.1039/B903609A

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