Issue 23, 2009
From the journal:

Organic & Biomolecular Chemistry

Synthesis and stereochemical determination of batzelladine C methyl ester†

Michael Butters,c   Christopher D. Davies,b   Mark C. Elliott,*a   Joseph Hill-Cousins,a   Benson M. Kariuki,a   Li-ling Ooi,a   John L. Wooda  and  Stuart V. Wordinghama  

* Corresponding authors

a Cardiff School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, UK
E-mail: elliottmc@cardiff.ac.uk
Fax: +44 (0)29 20874030
Tel: +44 (0)29 20874686

b AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

c AstraZeneca Process R&D Avlon/Charnwood, Avlon Works, Severn Road, Hallen, Bristol, UK

Abstract

Batzelladine C (3) is a tricyclic guanidine alkaloid of unknown stereochemistry at one centre as well as unknown absolute stereochemistry. The two possible diastereoisomers of the methyl ester corresponding to this compound have been synthesised, permitting the relative and absolute stereochemistry of this compound to be assigned.

Graphical abstract: Synthesis and stereochemical determination of batzelladine C methyl ester

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Article information

DOI
https://doi.org/10.1039/B914744F
Article type
Paper
Submitted
22 Jul 2009
Accepted
13 Aug 2009
First published
13 Oct 2009

Org. Biomol. Chem., 2009,7, 5001-5009

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Synthesis and stereochemical determination of batzelladine C methyl ester

M. Butters, C. D. Davies, M. C. Elliott, J. Hill-Cousins, B. M. Kariuki, L. Ooi, J. L. Wood and S. V. Wordingham, Org. Biomol. Chem., 2009, 7, 5001 DOI: 10.1039/B914744F

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