Issue 22, 2009
From the journal:

Organic & Biomolecular Chemistry

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents†

Carmen Nájeraa  and  José M. Sansano*a  

* Corresponding authors

a Departamento de Química Orgánica and Instituto de Síntesis Orgánica, Facultad de Ciencias, Universidad de Alicante, (Spain)
E-mail: cnajera@ua.es, jmsanano@ua.es
Fax: +34-965903549

Abstract

In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.

Graphical abstract: 1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

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Article information

DOI
https://doi.org/10.1039/B913066G
Article type
Perspective
Submitted
01 Jul 2009
First published
01 Oct 2009

Org. Biomol. Chem., 2009,7, 4567-4581

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1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

C. Nájera and J. M. Sansano, Org. Biomol. Chem., 2009, 7, 4567 DOI: 10.1039/B913066G

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