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Issue 22, 2009

Sensing of peptide hormones with dynamic combinatorial libraries of metal–dye complexes: the advantage of time-resolved measurements

Author affiliations

Abstract

A dynamic combinatorial library of metal–dye complexes was obtained by reacting aqueous solutions of the dyes Methyl Calcein Blue, Arsenazo I, and Xylenol Orange with CuCl2 and NiCl2. The mixture gave a characteristic UV-Vis response upon addition of the peptide hormones angiotensin I and angiotensin II. This allowed distinguishing pure samples of peptide hormones from mixtures. The discriminatory power of the sensor was enhanced when the several UV/Vis measurements were performed during the equilibration process of the library.

Graphical abstract: Sensing of peptide hormones with dynamic combinatorial libraries of metal–dye complexes: the advantage of time-resolved measurements

Supplementary files

Article information


Submitted
23 Jun 2009
Accepted
24 Jul 2009
First published
03 Sep 2009

Org. Biomol. Chem., 2009,7, 4598-4603
Article type
Paper

Sensing of peptide hormones with dynamic combinatorial libraries of metal–dye complexes: the advantage of time-resolved measurements

F. Zaubitzer, T. Riis-Johannessen and K. Severin, Org. Biomol. Chem., 2009, 7, 4598 DOI: 10.1039/B912400D

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