Issue 20, 2009

Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes

Abstract

A mandelamide ligand, derived from (S)-mandelic acid and (S)-phenylethanamine, catalyzes the addition of aryl-, alkyl- and silyl-alkynylzinc reagents to aromatic and heteroaromatic aldehydes with good yields and good to high enantioselectivities.

Graphical abstract: Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes

Supplementary files

Article information

Article type
Paper
Submitted
12 Jun 2009
Accepted
17 Jul 2009
First published
17 Aug 2009

Org. Biomol. Chem., 2009,7, 4301-4308

Catalytic enantioselective addition of terminal alkynes to aromatic aldehydes using zinc-hydroxyamide complexes

G. Blay, L. Cardona, I. Fernández, A. Marco-Aleixandre, M. C. Muñoz and J. R. Pedro, Org. Biomol. Chem., 2009, 7, 4301 DOI: 10.1039/B911592G

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