Issue 18, 2009

Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers

Abstract

The synthesis, cation binding and transmembrane conductive properties of a novel synthetic ion channel containing a redox-active ferrocene unit are described. Fluorescence spectroscopy was used to demonstrate that the channel supports multiple ion coordination and association constants for 1:1 and 1:2 (channel:cation) coordination for both Na+ and K+ were evaluated. Experiments using a black lipid membrane preparation revealed that this compound functioned effectively as an ion channel for both Na+ and K+. Concomitant 23Na NMR spectroscopy studies supported this finding and revealed a Na+ flux, at least 5 times higher than ion transport rates by monensin. Furthermore, oxidation of the redox-active centre (Fe2+ to Fe3+) effectively inhibited ion transport.

Graphical abstract: Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers

Article information

Article type
Paper
Submitted
14 Apr 2009
Accepted
10 Jun 2009
First published
22 Jul 2009

Org. Biomol. Chem., 2009,7, 3862-3870

Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers

M. Tsikolia, A. C. Hall, C. Suarez, Z. O. Nylander, S. M. Wardlaw, M. E. Gibson, K. L. Valentine, L. N. Onyewadume, D. A. Ahove, M. Woodbury, M. M. Mongare, C. D. Hall, Z. Wang, B. Draghici and A. R. Katritzky, Org. Biomol. Chem., 2009, 7, 3862 DOI: 10.1039/B907350G

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