The six-membered nitrogen-containing ring of the morphan scaffold, ubiquitous in natural products, is formed by an intramolecular aldol process of an aza-tethered dicarbonyl compound, leading to the first asymmetric synthesis of a morphan derivative using organocatalysis.
![Graphical abstract: Asymmetric synthesis of 2-azabicyclo[3.3.1]nonanes by a microwave-assisted organocatalysed tandem desymmetrisation and intramolecular aldolisation](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=B906835J&imageInfo.ImageIdentifier.Year=2009)
F. Diaba and J. Bonjoch, Org. Biomol. Chem., 2009, 7, 2517 DOI: 10.1039/B906835J
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