Issue 13, 2009

A new entry to phenanthridine ring systems via sequential application of Suzuki and the modified Pictet–Spengler reactions

Abstract

A mild, efficient and versatile method has been developed for the two step synthesis of phenanthridine ring systems using the Suzuki and the modified Pictet–Spengler strategy. The strategy involves synthesis of a substrate in which an aryl amine is tethered to an activated arene ring at the carbon ortho to the activated carbon nucleophile so as to facilitate the formation of phenanthridine ring viaπ-cyclization.

Graphical abstract: A new entry to phenanthridine ring systems via sequential application of Suzuki and the modified Pictet–Spengler reactions

Supplementary files

Article information

Article type
Paper
Submitted
20 Mar 2009
Accepted
09 Apr 2009
First published
22 May 2009

Org. Biomol. Chem., 2009,7, 2796-2803

A new entry to phenanthridine ring systems via sequential application of Suzuki and the modified Pictet–Spengler reactions

A. K. Mandadapu, M. Saifuddin, P. K. Agarwal and B. Kundu, Org. Biomol. Chem., 2009, 7, 2796 DOI: 10.1039/B905696C

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