Synthesis of functionalised HP-DO3A chelating agents for conjugation to biomolecules†
Abstract
Two novel bifunctional chelating agents (BFCAs) based on the structure of 10-(2-hydroxypropyl)-1,4,7-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) have been designed and synthesized. BFCAs are able to strongly coordinate metals (e.g.Gd(III)) and radiometals (e.g.90Y(III), 177Lu(III) and 111In(III)), and find applications in the synthesis of products for the imaging and treatment of several cancer types. Indeed, these two BFCAs have been employed in solid-phase